Cannabichromene (CBC) is a chemical compound native to the cannabis plant. Though CBC was first recognized in 1966, there’s a paucity of analysis on this versatile and vital compound. The prevailing proof means that CBC demonstrates vital therapeutic potential to advertise mind development, struggle most cancers, mitigate ache, improve temper, cut back irritation, and deal with pimples.
The Biosynthesis of CBC
Like tetrahydrocannabinol (THC) and cannabidiol (CBD), CBC is a product of an artificial course of that begins with the mom cannabinoid, cannabigerolic acid (CBGA). CBGA converts to CBCA (cannabichromenic acid) by the CBCA synthase enzyme. CBCA turns into CBC by decarboxylation, the method of utilizing warmth to vary the chemical properties of the compound in a means that amplifies its efficiency.
How CBC Interacts with the Physique
The endocannabinoid system (ECS) is the one most convincing argument that cannabis use is a wonderful remedy all human ought to not less than take into account. The ECS is comprised of molecular pathways referred to as cannabinoid receptors, endocannabinoids, and enzymes. THC has a robust binding affinity for CB 1 and CB 2, cannabinoid receptors that regulate temper and immunity. THC’s psychoactive and different therapeutic results are a direct results of the way in which it interacts with ECS receptors.
CBC additionally interacts with the ECS, however differently than THC. CBC has a poor binding affinity to CB1 and CB2, so it doesn’t induce the identical results as THC. Most notably, CBC doesn’t trigger any psychoactive results. Like CBD, CBC interacts with receptors aside from CB1 and CB2 together with vanilloid receptor 1 (TRPV1) and transient receptor potential ankyrin 1 (TRPA1). CBC’s interactions with these receptors trigger the physique to supply extra endocannabinoids (anandamide and 2-AG). Very similar to phytocannabinoids (cannabinoids similar to THC and CBD produced by crops like cannabis), endocannabinoids are chemical compounds that activate CB1 and CB2 in ways in which produce physiological and psychological results. The overwhelming majority of the time, these results improve bodily and psychological well being. It’s by elevating the expression of those endocannabinoids that CBC not directly interacts with cannabinoid receptors.
In comparison with the amount of analysis revealed on THC and CBD, there may be little or no literature exploring the medicinal use of CBC. Nonetheless, the prevailing proof may be very promising.
CBC Could Promote Mind Cell Progress
A 2013 examine discovered that CBC has the impact of selling mind cell development. The mind continues to develop into maturity, however development is proscribed to the hippocampus. This continued mind cell development is a course of known as neurogenesis. CBC, THC, and CBD have every been linked to elevated neurogenesis. Decreased neurogenesis has been implicated in anxiousness, melancholy, and impaired reminiscence.
Hashish’ impact on mind cell development led affiliate professor on the College of Saskatchewan’s neuropsychiatry analysis unit to say this: “Most ‘medication of abuse’ suppress neurogenesis. Solely marijuana promotes neurogenesis.”
A Doable Remedy For Tumors
Cells don’t stay eternally. In reality, they kill themselves throughout a course of referred to as apoptosis. Not like necrosis, one of these cell dying is programmed—it’s a part of the physique’s self-maintenance. Apoptosis protects the physique from cells that could be cancerous or contaminated. One of many major causes that cannabis is being researched as an anti-cancer agent is as a result of it’s believed to set off apoptosis.
Preliminary proof means that cannabinoids (together with CBC) may go synergistically to cease tumor development in numerous most cancers fashions. Along with inducing apoptosis, cannabinoids additionally intrude with a tumor’s potential to proliferate, or divide.
THC, CBD, and CBN have taken the highlight in most cancers analysis, however CBC’s impact of accelerating endocannabinoids may contribute to cannabis’ anti-cancer results. It is because CB1 and CB2 play a big position in facilitating cell well being, and endocannabinoids have a robust binding affinity for these two receptors.
Continual ache impacts 50 million adults in the USA every year, a considerable 20.four p.c of the inhabitants. Opioids are a standard and quickly efficient remedy choice for persistent ache sufferers, however they arrive with the horrifying and deadly penalties of dependancy and overdose.
In a 2010 animal examine utilizing rats, CBC and CBD had been discovered to cut back ache by interacting with a number of molecular pathways situated on the backbone. In a time when the nationwide disaster of opioid dependancy has sewn worry, distrust, and hopelessness into the relationships between sufferers, their docs, and the pharmaceutical business, cannabis presents an thrilling different to opioids. Like CBD, CBC is non-psychoactive. Meaning it doesn’t induce the mind-altering results of THC. Though cannabis will be addictive, it isn’t attainable to fatally overdose from the plant.
If scientists and researchers are in a position to isolate the analgesic properties of cannabinoids like CBC and CBD, persistent ache sufferers could discover themselves on a brand new and much much less treacherous street to reduction.
CBC Could Operate As An Anti-Depressant
For those who’ve consumed cannabis, you have got skilled what can occur to an individual’s temper when the ECS is supercharged with cannabinoids. Some describe the feeling as euphoric, uplifting, or stress-free. One factor is obvious—typically, a cannabis excessive feels good.
A 2010 examine on mice discovered that THC, CBD, and CBC exhibit anti-depressant exercise and should “contribute to the general mood-elevating properties of cannabis.” This may occasionally clarify why a considerable amount of individuals with melancholy, anxiousness, or different temper problems select to self-medicate with weed.
CBC Has Anti-Inflammatory Properties
This 2010 examine discovered that CBC exhibited stronger anti-inflammatory results than THC, and that it achieved these results with out activating CB1 or CB2. This proof means that collectively, CBC and THC make a strong anti-inflammatory group. Whereas that analysis demonstrated CBC’s results on edema, this 2012 examine discovered that CBC was efficient at decreasing irritation of the gastrointestinal tract as effectively.